Company Filing History:
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Years Active: 2009-2014
Title: Innovations in Gene Delivery: The Contributions of WenHua Tang
Introduction
WenHua Tang is a notable inventor based in Arlington, VA, who has made significant contributions to the field of gene delivery systems. With a total of two patents to his name, his work focuses on developing targeted therapies for cancer treatment. His innovative approaches utilize advanced technologies to enhance gene transfer efficiency, particularly in human cancer cells.
Latest Patents
WenHua Tang's latest patents include groundbreaking research on antibody fragment-targeted immunoliposomes for systemic gene delivery. One of his patents describes a targeted vector that enhances gene transfer to human hepatocellular carcinoma (HCC) cells in vitro. This technology employs cationic liposomes that are covalently conjugated with the monoclonal antibody AF-20, which recognizes a specific glycoprotein abundantly expressed on HCC and other cancer cells. The quantitative binding analysis demonstrated a specific association of these targeted liposomes with human HCC cells, leading to a remarkable 40-fold enhancement in gene expression in HuH-7 cells compared to control liposomes. Another patent focuses on nucleic acid-immunoliposome compositions that are therapeutically useful, comprising cationic liposomes, a single-chain antibody fragment binding to transferrin receptors, and nucleic acids encoding wild-type p53. These compositions are designed to target cancer cells expressing transferrin receptors, offering potential therapeutic applications for various cancers.
Career Highlights
Throughout his career, WenHua Tang has worked with prominent organizations, including Synergene Therapeutics, Inc. and Georgetown University. His experience in these institutions has allowed him to collaborate with leading experts in the field and contribute to significant advancements in cancer therapy.
Collaborations
WenHua Tang has collaborated with notable colleagues, including Liang Xin Xu and Cheng-Cheng Huang. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of his research.
Conclusion
WenHua Tang's innovative work in gene delivery systems represents a significant advancement in cancer treatment methodologies. His patents reflect a commitment to improving therapeutic outcomes for patients suffering from various forms of cancer.