Wenhai Liu is a notable inventor based in Plantsville, Connecticut, who has made significant contributions to the field of biotechnology. He holds a total of six patents, showcasing his innovative approach to medical science and cancer treatment.

Latest Patents

Among his latest patents, Liu has developed a modified form of exotoxin A that features reduced immunogenic T cell and/or B cell epitopes. This invention provides a novel exotoxin A (PE) with an amino acid sequence that includes substitutions of one or more B-cell and/or T-cell epitopes. The invention also encompasses related chimeric molecules, nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Furthermore, it outlines methods for treating or preventing cancer in mammals, inhibiting the growth of target cells, and producing both the PE and the chimeric molecule. Another significant patent involves pseudomonas exotoxin A with fewer immunogenic B cell epitopes, which similarly includes specific amino acid substitutions and related methodologies for cancer treatment.

Career Highlights

Wenhai Liu is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this prestigious institution has allowed him to focus on groundbreaking research that has the potential to impact cancer therapies significantly.

Collaborations

Liu has collaborated with esteemed colleagues such as Ira H. Pastan and Masanori Onda, contributing to the advancement of knowledge and innovation in his field.

Conclusion

Wenhai Liu's contributions to biotechnology and cancer treatment through his patents reflect his dedication to improving medical science. His innovative work continues to pave the way for future advancements in the field.

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