The United States of America, As Represented by the Secretary, Department of Health and Human Services

Wenhai Liu

Ira H Pastan

Masanori Onda

Richard Beers

Ronit Mazor

Aaron Vassall

Jaime Eberle

The invention provides aexotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

exotoxin A with less immunogenic T cell and/or B cell epitopes

The invention provides aexotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463, Y481, L516, R563, D581, D589, and K606, wherein the amino acid residues are defined by reference to SEQ ID NO: 1. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

Pseudomonas exotoxin A with less immunogenic B cell epitopes

Pseudomonas exotoxin a with less immunogenic T cell and/or B cell epitopes

[object Object]

Growing community of inventors

Plantsville, CT, United States of America

Wenhai Liu