Company Filing History:
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Years Active: 2018
Title: Wendy Toussaint: Innovator in Transgenic Mouse Research
Introduction
Wendy Toussaint is a prominent inventor based in Ghent, Belgium. She has made significant contributions to the field of biomedical research, particularly in the development of transgenic mouse models. With a total of two patents to her name, her work focuses on understanding the role of senescent cells in age-related disorders and cancer.
Latest Patents
Wendy Toussaint's latest patents include innovative transgenic mouse models designed for specific research purposes. The first patent describes a transgenic mouse that has a transgene capable of converting a prodrug into a cytotoxic compound specifically in senescent cells. This invention allows researchers to study the impact of senescent cells on age-related disorders or age-sensitive traits. The transgene utilizes a p16 promoter sequence to control the expression of an enzyme that selectively targets senescent cells, thereby delaying the progression of age-related conditions. Additionally, the 3MR mouse model included in this patent expresses bioluminescent and fluorescent markers, enabling visualization of senescent cells.
The second patent focuses on a transgenic mouse that helps determine the role of senescent cells in cancer. This model also employs a p16 promoter sequence to preferentially express a protein in senescent cells. The protein either induces apoptosis directly or converts a prodrug into a cytotoxic compound. By injecting syngeneic tumor cells or incorporating a second transgene that promotes tumor formation, this model allows for the investigation of how removing senescent cells may influence tumor development.
Career Highlights
Wendy Toussaint has worked at notable research institutions, including the Buck Institute for Research on Aging and Erasmus University Medical Center Rotterdam. Her career is marked by a commitment to advancing our understanding of cellular aging and its implications for health.
Collaborations
Throughout her career, Wendy has collaborated with esteemed colleagues such as Judith Campisi and Marco Demaria. These partnerships have further enriched her research and contributed to the scientific community's knowledge of senescence and its effects on aging and cancer.
Conclusion
Wendy Toussaint's innovative work in developing transgenic mouse models has significantly advanced the field of biomedical research. Her patents provide valuable tools for studying the complexities of senescent cells in relation to age-related disorders and cancer. Through her contributions, she continues to