The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Mar. 25, 2016
Buck Institute for Research on Aging, Novato, CA (US);
Erasmus University Medical Center Rotterdam, Rotterdam OT, NL;
James Mitchell, Boston, MA (US);
Wendy Toussaint, Ghent, BE;
Judith Campisi, Berkeley, CA (US);
Marco Demaria, Groningen, NL;
Francis Rodier, Novato, CA (US);
Remi-Martin Laberge, San Francisco, CA (US);
James Mitchell, Boston, MA (US);
Jan H. J. Hoeijmakers, Rotterdam, NL;
Wendy Toussaint, Ghent, BE;
Buck Institute for Research on Aging, Novato, CA (US);
Erasmus University Medical Center Rotterdam, Rotterdam, NL;
Abstract
This invention provides a transgenic mouse with a p16promoter sequence that controls expression of a protein such that it is expressed preferentially in senescent cells. The protein either directly induces apoptosis, or converts a prodrug to a cytotoxic compound. In addition, the mouse is injected with syngeneic tumor cells, or has second transgene that causes tumors to form. Removing senescent cells from the mouse may result in the formation of fewer tumors.