Company Filing History:
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Years Active: 2018
Title: Jan H J Hoeijmakers: Innovator in Transgenic Mouse Research
Introduction
Jan H J Hoeijmakers is a prominent inventor based in Rotterdam, Netherlands. He has made significant contributions to the field of aging research through his innovative work on transgenic mice. With a total of two patents to his name, Hoeijmakers is recognized for his groundbreaking inventions that explore the role of senescent cells in age-related disorders and cancer.
Latest Patents
Hoeijmakers' latest patents include a transgenic mouse that has a transgene capable of converting a prodrug into a cytotoxic compound specifically in senescent cells. This invention allows researchers to study the impact of senescent cells on age-related disorders or traits. The transgene features a p16 promoter sequence that regulates the expression of an enzyme, which, when activated by the prodrug, selectively eliminates senescent cells. This process can delay the progression of age-related disorders. Another notable patent involves a transgenic mouse designed to determine the role of senescent cells in cancer. This mouse also utilizes a p16 promoter sequence to express a protein that induces apoptosis or converts a prodrug into a cytotoxic compound, potentially reducing tumor formation when senescent cells are removed.
Career Highlights
Throughout his career, Jan H J Hoeijmakers has worked with esteemed institutions such as the Buck Institute for Research on Aging and Erasmus University Medical Center Rotterdam. His research has significantly advanced the understanding of cellular senescence and its implications for aging and cancer.
Collaborations
Hoeijmakers has collaborated with notable researchers in the field, including Judith Campisi and Marco Demaria. Their collective efforts have contributed to the advancement of knowledge regarding the effects of senescent cells on health and disease.
Conclusion
Jan H J Hoeijmakers is a distinguished inventor whose work on transgenic mice has opened new avenues for research in aging and cancer. His innovative patents reflect a commitment to understanding the complexities of cellular senescence and its impact on health.
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