The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2018
Filed:
Mar. 11, 2016
Buck Institute for Research on Aging, Novato, CA (US);
Erasmus University Medical Center Rotterdam, Rotterdam OT, NL;
James Mitchell, Boston, MA (US);
Wendy Toussaint, Ghent OT, BE;
Judith Campisi, Berkeley, CA (US);
Marco Demaria, San Francisco, CA (US);
Remi-Martin Laberge, Novato, CA (US);
Francis Rodier, Novato, CA (US);
James Mitchell, Boston, MA (US);
Jan H. J. Hoeijmakers, Rotterdam, NL;
Wendy Toussaint, Ghent, BE;
Buck Institute for Research on Aging, Novato, CA (US);
Erasmus University Medical Center Rotterdam, Rotterdam, NL;
Abstract
This invention provides a transgenic mouse for studying the role of senescent cells on an age-related disorder or an age-sensitive trait. The transgene contains a p16 promoter sequence that controls expression of an enzyme so as to cause the enzyme to be expressed in senescent cells in the mouse. The enzyme converts a prodrug to a cytotoxic agent, so that treating the mouse with the prodrug results in the prodrug selectively killing the senescent cells. As a result, progression of an age-related disorder or an age-sensitive trait is delayed. Included is the 3MR mouse model, which also expresses bioluminescent and fluorescent markers under control of the p16 promoter so that senescent cells in the mice can be visualized.