Company Filing History:
Years Active: 2010
Title: Innovative Contributions of Weiping Shen in Pharmaceutical Research
Introduction
Weiping Shen, an accomplished inventor based in Shanghai, China, has made notable contributions to the field of pharmaceutical research. With a total of two patents to his name, he is recognized for his innovative approaches in the development of combretastatin derivatives, which hold promise for cancer treatment.
Latest Patents
Shen's latest patents include groundbreaking work titled "Preparation and the use of ethoxy combretastatins and their prodrugs." This invention outlines a total synthesis process for novel ethoxy combretastatins and their prodrugs. These combretastatins feature a chemical modification with an ethoxy group on the 4'-position of their B aryl ring, which enhances their solubility and therapeutic potential. The invention further details the conversion of hydroxyl groups on the 3'-position to prodrugs, illustrating how 3'-amino combretastatins can be modified to form soluble amino acid amide prodrugs. Ethoxy combretastatins exhibit potent tubulin polymerization inhibitory activity, making them valuable in the treatment of tumors and neovascular growth.
Another significant patent by Shen is titled "Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof." This patent discloses combretastatin derivatives characterized by alkyl groups and fluorine atoms, capable of inhibiting microtubule polymerization. These derivatives show potential as therapeutic agents in the treatment of tumors and neovascular conditions, contributing to the advancement of cancer therapies.
Career Highlights
Weiping Shen is affiliated with Zhejiang Dade Pharmaceutical Group Co., Ltd., where his innovative work continues to thrive. His research has led to advancements in drug development, particularly concerning the modulation of tubulin polymerization, a critical factor in tumor progression.
Collaborations
Throughout his career, Shen has collaborated with notable peers, including Jianping Wang and Jianguo Wang. These collaborative efforts have enriched his research and contributed to the successful development of his patented inventions.
Conclusion
Weiping Shen is a remarkable inventor whose contributions to the pharmaceutical field through his innovative patents have significant implications for cancer treatment. His work exemplifies the importance of innovation in developing therapeutic solutions, highlighting his commitment to advancing medical science.