The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7786098 B1

PDF
Full Text
Expired
Date of Patent:
Aug. 31, 2010

Filed:

Nov. 22, 2006
Applicants:

Weiping Shen, Shanghai, CN;

Jianping Wang, Yiwu, CN;

Jianguo Wang, Yiwu, CN;

Hongmei Jin, Shanghai, CN;

Feng Qian, Shanghai, CN;

Fei Wang, Shanghai, CN;

Inventors:

Weiping Shen, Shanghai, CN;

Jianping Wang, Yiwu, CN;

Jianguo Wang, Yiwu, CN;

Hongmei Jin, Shanghai, CN;

Feng Qian, Shanghai, CN;

Fei Wang, Shanghai, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/661 (2006.01); A61K 31/085 (2006.01); A61K 31/164 (2006.01); A61K 31/136 (2006.01); A61P 35/00 (2006.01); C07C 43/205 (2006.01); C07C 211/43 (2006.01); C07C 237/00 (2006.01); C07F 9/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Ris alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.


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