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Title: Innovator Spotlight: Wanli Bi
Introduction
Wanli Bi is a prominent inventor based in San Ramon, California, recognized for his significant contributions to the field of nucleic acid amplification. With a total of six patents to his name, Bi showcases a remarkable dedication to advancing biotechnological methods and applications.
Latest Patents
One of Wanli Bi's latest patents is titled "Nucleic acid amplification using a reversibly modified oligonucleotide." This innovative method provides a way to amplify a target nucleic acid sequence or signal using an amplification reaction mixture that includes at least one reversibly modified oligonucleotide. This oligonucleotide possesses a non-hydroxyl group 3' end, which can be converted into a hydroxyl 3' end upon exposure to specific chemicals, irradiation, or temperature variations. In addition, he has developed modified oligonucleotides and their applications, which disclose primers that feature certain modified nucleobases in the 3' terminal region. This design aims to minimize the formation of primer-dimers during amplification reactions, enhancing the efficiency of such processes.
Career Highlights
Throughout his career, Wanli Bi has worked with prominent organizations, including Applied Biosystems, LLC. His expertise and innovative thinking have allowed him to remain at the forefront of nucleic acid research, contributing valuable insights and advancements to the field.
Collaborations
Wanli Bi has collaborated with notable colleagues, including Khairuzzaman Bashar Mullah and Zhaochun Ma. These partnerships have fostered an environment of creativity and shared knowledge, further driving innovation in nucleic acid amplification methodologies.
Conclusion
Wanli Bi's work as an inventor exemplifies the importance of innovation in biotechnology. His latest patents not only advance scientific understanding but also have the potential to transform practices in nucleic acid research and applications. With ongoing collaborations and a strong professional background, Bi continues to be an influential figure in the realm of inventions related to molecular biology.