W H Irwin McLean

Title: W H Irwin McLean: Innovator in Genetic Treatments

Introduction

W H Irwin McLean is a notable inventor based in Perthshire, GB. He has made significant contributions to the field of genetic treatments, particularly in addressing rare genetic disorders. His innovative approach has led to the development of a unique method for treating pachyonychia congenita.

Latest Patents

McLean holds a patent for "Methods and compositions for treating pachyonychia congenita." This patent outlines a method for treating pachyonychia congenita (PC) by identifying a genetic mutation that contributes to the condition. The process involves preparing a siRNA sequence that inhibits the expression of the identified mutation and administering the siRNA to a cell of a subject afflicted with PC. The treatment can include silencing both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified to enhance the effectiveness of the treatment.

Career Highlights

Throughout his career, McLean has been associated with Transderm, Inc., where he has focused on developing innovative solutions for skin-related genetic disorders. His work has garnered attention in the scientific community for its potential to improve the quality of life for individuals affected by pachyonychia congenita.

Collaborations

McLean has collaborated with notable colleagues, including Roger Louis Kaspar and Robyn Patricia Hickerson. These collaborations have contributed to the advancement of research in genetic treatments and have fostered a collaborative environment for innovation.

Conclusion

W H Irwin McLean's contributions to the field of genetic treatments, particularly for pachyonychia congenita, highlight his role as an innovator in medical science. His work continues to inspire advancements in the treatment of genetic disorders.