Location History:
- Shrewsbury, MA (US) (1997 - 2002)
- Moscow, RU (2000 - 2006)
Company Filing History:
3 out of 1,556 
2 out of 98 
1 out of 18 Years Active: 1997-2006
Title: Valeri Metelev: Innovator in Hybrid Oligonucleotide Technology
Introduction
Valeri Metelev is a prominent inventor based in Moscow, Russia, known for his significant contributions to the field of oligonucleotide technology. With a total of six patents to his name, he has made remarkable advancements that enhance the properties of hybrid oligonucleotides.
Latest Patents
Metelev's latest patents focus on hybrid oligonucleotide phosphorothioates. These inventions provide hybrid oligonucleotides that feature phosphorothioate or phosphorodithioate internucleotide linkages, incorporating both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides exhibit superior properties, including enhanced duplex formation with RNA, increased nuclease resistance, and effective RNase H activation.
Career Highlights
Throughout his career, Valeri Metelev has worked with esteemed institutions, including the University of Massachusetts and Hybridon, Inc. His work has significantly impacted the field of molecular biology and biotechnology, paving the way for new therapeutic applications.
Collaborations
Metelev has collaborated with notable professionals in his field, including Sudhir Agrawal and Eliezer Rapaport. These collaborations have further enriched his research and innovations.
Conclusion
Valeri Metelev's contributions to hybrid oligonucleotide technology demonstrate his expertise and commitment to advancing scientific knowledge. His innovative patents continue to influence the field and hold promise for future developments.