The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2000
Filed:
Jun. 07, 1995
Applicant:
Inventors:
Valeri Metelev, Moscow, RU;
Sudhir Agrawal, Shrewsbury, MA (US);
Assignee:
University of Massachusetts Worcester, Worcester, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; A01N / ; A01N / ;
U.S. Cl.
CPC ...
536 245 ; 514 44 ; 536 231 ; 536 253 ; 536 2533 ; 536 257 ; 424601 ;
Abstract
The invention provides hybrid oligonucleotides having phosphorothioate or phosphorodithioate internucleotide linkages, and both deoxyribonucleosides and ribonucleosides or 2'-substituted ribonucleosides. Such hybrid oligonucleotides have superior properties of duplex formation with RNA, nuclease resistance, and RNase H activation.