Location History:
- Vigevano Pavia, IT (2001)
- Vigevano, IT (1997 - 2003)
Company Filing History:
Years Active: 1997-2003
Title: Umberto Breme: Innovator in Microbial Production of Taxanes and Anticancer Agents
Introduction
Umberto Breme, an accomplished inventor based in Vigevano, Italy, has made significant contributions to the field of pharmaceutical microbiology. His innovative approach has led to the development of multiple patents that focus on microbial processes for producing vital medicinal compounds.
Latest Patents
Breme holds six patents, with two of his latest inventions showcasing his expertise in the production of essential therapeutic agents.
1. **Paclitaxel production by actinomycetes**: This invention pertains to the use of specific microorganisms that produce taxanes, particularly paclitaxel, which is crucial in cancer therapy. Breme's work centers on isolating actinomycetes from plants, detailing a method to cultivate these microorganisms, which belong to genera such as Streptomyces and Kitasatosporia, with Kitasatosporia sp. CECT 4991 being a significant example.
2. **Process for preparing doxorubicin**: This patent outlines a method for enhancing the production of daunorubicin and doxorubicin through genetic mutation of microorganisms. By altering certain genes involved in daunorubicin metabolism, Breme aims to improve the yield of these important anticancer drugs.
Career Highlights
Umberto Breme's career is marked by his dedication to advancing microbiological techniques in drug production. Working at Pharmacia & Upjohn S.p.a., he has focused on harnessing the potential of microbial systems to meet the demands of modern medicine. His research has placed him at the forefront of pharmaceutical innovation, especially in the realm of producing complex natural products.
Collaborations
Throughout his career, Breme has collaborated with esteemed colleagues such as Anna Luisa Colombo and Sharee L Otten. These partnerships not only highlight his commitment to teamwork but also enhance the sharing of knowledge and expertise necessary for groundbreaking research and development in the pharmaceutical sector.
Conclusion
Umberto Breme's innovative approach to microbial production of critical pharmaceuticals positions him as an influential figure in the field. His patents reflect a combination of scientific rigor and creativity that continues to contribute to advancements in cancer treatment and therapeutic methodologies. As the pharmaceutical landscape evolves, the impact of Breme's inventions will likely resonate in the medical community for years to come.