The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 03, 2001
Filed:
Jan. 14, 1999
Applicant:
Inventors:
Silvia Filippini, Milan, IT;
Natalia Lomovskaya, Madison, WI (US);
Leonid Fonstein, Madison, WI (US);
Anna Luisa Colombo, Milan, IT;
C. Richard Hutchinson, Cross Plains, WI (US);
Sharee L. Otten, Madison, WI (US);
Umberto Breme, Vigevano, IT;
Assignee:
Pharmacia & Upjohn, S.P.A., Milan, IT;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 1/956 ; C12N 9/02 ; C12N 1/553 ; C12N 1/563 ; C12N 1/574 ;
U.S. Cl.
CPC ...
C12P 1/956 ; C12N 9/02 ; C12N 1/553 ; C12N 1/563 ; C12N 1/574 ;
Abstract
The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.