Company Filing History:
2 out of 110 
1 out of 266 Years Active: 2008-2015
Title: Innovations of Toshio Kanda in Transgenic Silkworm Technology
Introduction
Toshio Kanda is a notable inventor based in Tsukuba, Japan, recognized for his contributions to biotechnology through the development of transgenic silkworms. His innovative work has led to the creation of methods that enhance the production of recombinant proteins and antibodies.
Latest Patents
Kanda holds two significant patents. The first patent involves the creation of antibody-producing transgenic silkworms. This invention includes a promoter of a DNA encoding a protein specifically expressed in the silk gland, along with a DNA encoding a recombinant antibody. The expression of this antibody is regulated by the promoter, allowing the silkworms to secrete the recombinant antibody into the silk gland. The antibodies produced from these transgenic silkworms have been confirmed to be active.
The second patent focuses on methods for producing proteins using a silkworm middle silk gland-specific gene expression system. In this innovation, transgenic silkworms were developed that express GFP, regulated by the sericin gene promoter. Observations revealed fluorescence in the middle silk glands of the last instar larvae, indicating successful secretion of GFP into the gland lumen. Ultimately, GFP was spun into cocoon filaments, resulting in cocoons containing substantial amounts of GFP. This method demonstrates the potential for producing recombinant proteins in the middle silk glands of silkworms.
Career Highlights
Throughout his career, Kanda has worked with esteemed organizations such as the National Institute of Agrobiological Sciences and Nitto Boseki Co., Ltd. His research has significantly advanced the field of biotechnology, particularly in the area of protein production.
Collaborations
Kanda has collaborated with notable colleagues, including Toshiki Tamura and Isao Kobayashi. Their joint efforts have contributed to the success of his innovative projects.
Conclusion
Toshio Kanda's work in developing transgenic silkworms has opened new avenues for the production of valuable proteins and antibodies. His patents reflect a significant advancement in biotechnology, showcasing the potential of silkworms as bioreactors for recombinant protein production.
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