Toshinobu Nouchi

Title: **The Innovative Contributions of Toshinobu Nouchi**

Introduction

Toshinobu Nouchi, an accomplished inventor from Kumamoto, Japan, has made significant strides in the fields of virology and biochemistry. With four patents to his name, his work revolves around innovative methods for handling viruses and protein solutions, which contributes to advancements in medical and therapeutic research.

Latest Patents

Among Toshinobu Nouchi's notable patents is a **Method for Propagating Influenza Virus.** This innovative technique enables the large-scale production of the influenza virus. The method involves the removal or reduction of a trypsin inhibitor that is secreted into the cultures of MDCK cells, which are derived from dog kidneys. By washing these cells with a culture medium or buffer, Nouchi’s method allows for the inoculation of the influenza virus into the cells, followed by a culture period that includes trypsin supplementation to enhance virus propagation.

Another significant invention is the **Method for Removing Multimers of Human Serum Albumin.** This patent describes a process for separating multimers of human serum albumin from a solution. By utilizing an anion-exchanger equilibrated with a buffer containing a specific salt concentration (ranging from 10 to 150 mM) and a pH value between 5 to 9.5, this method effectively purifies the human serum albumin solution, enhancing its usability in various medical applications.

Career Highlights

Throughout his career, Toshinobu Nouchi has collaborated with prestigious institutions. He has been associated with the Juridical Foundation Chemo-sero-therapeutic Research Institute and Teijin Limited. His innovative contributions have not only advanced his career but also significantly impacted the fields of biotechnology and therapeutic research.

Collaborations

In the course of his work, Nouchi has collaborated with esteemed colleagues such as Hiroshi Mizokami and Yoshitaka Tajima. These collaborations have allowed for the exchange of knowledge and ideas, fostering an environment of innovation and excellence within their projects.

Conclusion

Toshinobu Nouchi exemplifies the spirit of innovation through his groundbreaking patents and collaborative efforts. His work in the methods of virus propagation and protein purification continues to inspire advancements in therapeutic techniques, illustrating the vital role of inventors in enhancing medical science and technology.