Tartu, Estonia

Toomas Silla

USPTO Granted Patents = 2 


Average Co-Inventor Count = 9.6

ph-index = 1

Forward Citations = 4(Granted Patents)


Company Filing History:


Years Active: 2010-2013

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2 patents (USPTO):Explore Patents

Title: Innovations by Toomas Silla: Pioneering Viral Expression Plasmids

Introduction

Toomas Silla, an accomplished inventor based in Tartu, Estonia, has made significant contributions to the field of biotechnology through his innovative patents. With two patents to his name, Silla's work focuses primarily on viral expression plasmids that enhance the production of proteins, antibodies, enzymes, and virus-like particles. His inventions are crucial for advancing cell-based assays and understanding viral mechanisms.

Latest Patents

Toomas Silla's latest patents reflect his expertise in plasmid technology. The first patent details the use of viral expression plasmids for the stable maintenance and replication function provided by the EBV FR-element in the presence of BPV-1 E2 protein and PyV large T-antigen (LT). This groundbreaking work describes how these plasmids can enhance the production of essential biological products.

The second patent elaborates on vectors and cell lines that support extended episomal maintenance replication of hybrid plasmids. Silla's findings indicate that the BPV-1 E2 protein-dependent minichromosome maintenance element can maintain replication stability in varying cellular environments. His research demonstrates that the maintenance and replication activation functions from different viruses can work together to support gene product expression efficiently.

Career Highlights

Toomas Silla has worked with notable organizations such as Kosagen Cell Factory OÜ and Icosagen Cell Factory OÜ, where he has honed his skills in the biotechnological field. His deep understanding of plasmid biology and viral mechanisms positions him as a leader in the development of innovative solutions for biotechnology applications.

Collaborations

Throughout his career, Silla has collaborated with talented individuals such as Ingrid Tagen and Jelizaveta Geimanen, contributing to a culture of innovation within his teams. These collaborations have not only produced significant advancements in cell-based assays but also fostered the development of new technologies in the biotech sector.

Conclusion

Toomas Silla’s work in developing viral expression plasmids showcases his innovative spirit and dedication to advancing biotechnology. With two important patents under his belt, he continues to be a driving force in the quest for improved methods of protein production and gene expression. His contributions are likely to have lasting impacts in the fields of medicine and biotechnology, paving the way for further innovations.

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