Tomasz H Kowalczyk

Title: Innovations by Tomasz H Kowalczyk

Introduction

Tomasz H Kowalczyk is an accomplished inventor based in University Heights, OH (US). He holds 3 patents that reflect his significant contributions to the field of nucleic acid research and technology. His work focuses on enhancing the stability and efficacy of nucleic acid complexes, which are crucial for various biomedical applications.

Latest Patents

One of his latest patents is titled "Lyophilizable and enhanced compacted nucleic acids." This invention highlights how counterions of polycations used to compact nucleic acids can profoundly affect the shape and stability of the particles formed. The shape of these particles is associated with differential serum nuclease resistance and colloidal stability. A key parameter for determining these properties is turbidity, which is easy to measure. Additionally, the shape of compacted nucleic acid complexes influences their suitability and efficacy for transfecting cells into a mammalian body. The patent also discusses how counterions like acetate can protect these complexes from the adverse effects of lyophilization.

Another significant patent is the "Method of nucleic acid compaction." This invention describes an automated nucleic acid compaction device designed for analyzing and compacting nucleic acid complexes into unimolecular nucleic acid particles. The device includes a container support and agitation system, a measuring and testing system, and a dispensing system, all controlled by a sophisticated control system. This system can operate based on predetermined formulations or feedback data from the measuring and testing system. A preferred embodiment of the device operates in a closed-loop system, featuring a monitoring system with a submersible probe that provides real-time data to the controller.

Career Highlights

Throughout his career, Tomasz has worked with notable companies, including Copernicus Therapeutics, Inc. His innovative work has contributed to advancements in the field of nucleic acid technology, making significant impacts in research and development.

Collaborations

Tomasz has collaborated with esteemed colleagues such as Mark J Cooper and Murali Krishna Pasumarthy, further enhancing the scope and impact of his research.

Conclusion

Tomasz H Kowalczyk is a prominent inventor whose work in nucleic acid technology has led to valuable patents and advancements in the field. His contributions continue to influence research and applications in biotechnology.