The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Sep. 08, 2003
Mark J. Cooper, Moreland Hills, OH (US);
Murali K. Pasumarthy, Twinsburg, OH (US);
Tomasz H. Kowalczyk, University Heights, OH (US);
Maureen Costello, Beachwood, OH (US);
Mark J. Cooper, Moreland Hills, OH (US);
Murali K. Pasumarthy, Twinsburg, OH (US);
Tomasz H. Kowalczyk, University Heights, OH (US);
Maureen Costello, Beachwood, OH (US);
Copernicus Therapeutics, Inc., Cleveland, OH (US);
Abstract
Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body. Moreover, counterions such as acetate can protect compacted nucleic acid complexes from adverse effects of lyophilization.