Murali Krishna Pasumarthy

Title: Murali Krishna Pasumarthy: Innovator in Nucleic Acid Technologies

Introduction

Murali Krishna Pasumarthy is a notable inventor based in Willoughby Hills, OH (US). He has made significant contributions to the field of nucleic acid technologies, holding a total of 3 patents. His work focuses on enhancing the stability and efficacy of nucleic acid complexes, which are crucial for various biomedical applications.

Latest Patents

One of his latest patents is titled "Lyophilizable and enhanced compacted nucleic acids." This invention highlights how counterions of polycations used to compact nucleic acids can profoundly affect the shape and stability of the resulting particles. The shape of these particles is associated with differential serum nuclease resistance and colloidal stability. A key aspect of this patent is the turbidity parameter, which serves as a surrogate for determining these properties in an easy-to-measure format. Additionally, the shape of the compacted nucleic acid complexes influences their suitability and efficacy for transfecting cells into a mammalian body. The patent also discusses how counterions, such as acetate, can protect these complexes from the adverse effects of lyophilization.

Another significant patent is the "Method of nucleic acid compaction." This invention describes an automated nucleic acid compaction device designed for analyzing and compacting nucleic acid complexes into unimolecular nucleic acid particles. The device includes a container support and agitation system, a measuring and testing system, and a dispensing system, all controlled by a sophisticated control system. This system can operate based on predetermined formulations or feedback data from the measuring and testing system. A preferred embodiment of the device operates in a closed-loop system, featuring a monitoring system with a submersible probe that provides real-time data to the controller. Once the desired level of nucleic acid compaction is achieved, the controller halts the dispensing and mixing processes.

Career Highlights

Throughout his career, Murali Krishna Pasumarthy has worked with various companies, including Copernicus Therapeutics, Inc. His innovative work has positioned him as a key player in the development of advanced nucleic acid technologies.

Collaborations

He has collaborated with notable individuals in the field, including Mark J Cooper and Tomasz H Kowalczyk. These collaborations have further enriched his research and development efforts.

Conclusion

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