Tom R Covey

Title: Tom R Covey: Innovator in Frontal Affinity Chromatography

Introduction

Tom R Covey is a notable inventor based in Dundas, CA. He has made significant contributions to the field of chromatography, particularly through his innovative patent related to frontal affinity chromatography and mass spectrometry.

Latest Patents

Tom R Covey holds a patent for "Frontal affinity chromatography/MALDI tandem mass spectrometry." This invention utilizes sol-gel derived monolithic silica columns that contain entrapped dihydrofolate reductase for the frontal affinity chromatography of small molecule mixtures. The output from the column is combined with a second stream containing the matrix molecule (HCCA) and is directly deposited onto a conventional MALDI plate. This setup is controlled by a computer-operated x-y stage, which creates a semi-permanent record of the FAC run. The integration of MALDI MS allows for a decoupling of the FAC and MS methods, enabling the use of significantly higher ionic strength buffers for FAC studies. This advancement leads to better retention of protein activity over multiple runs.

Career Highlights

Throughout his career, Tom R Covey has demonstrated a commitment to advancing scientific knowledge and technology. His work has been instrumental in enhancing the efficiency and effectiveness of chromatographic techniques.

Collaborations

Tom has collaborated with notable colleagues, including William R Davidson and Bori Shushan, contributing to a rich exchange of ideas and innovations in their field.

Conclusion

Tom R Covey's contributions to frontal affinity chromatography and mass spectrometry exemplify the impact of innovative thinking in scientific research. His work continues to influence the field and inspire future advancements.