Company Filing History:
Years Active: 2005
Title: Todd Appleby: Innovator in Polymerase Inhibition
Introduction
Todd Appleby is a notable inventor based in Laguna Niguel, California. He has made significant contributions to the field of biotechnology, particularly in the development of polymerase inhibitors. His innovative work has led to the filing of a patent that addresses critical challenges in RNA polymerase activity.
Latest Patents
Todd Appleby holds a patent for "Inhibitors for de novo-RNA polymerases and methods of identifying targets for same." This patent describes a polymerase inhibitor that features a first moiety coupled to a second moiety via an optional linker. The first moiety binds to an initiation nucleotide binding site of a polymerase, forming at least two hydrogen bonds with an RNA template strand associated with the polymerase. The second moiety comprises a compound that binds to a site proximal to the nucleotide binding site of the polymerase, thereby increasing the affinity of the polymerase inhibitor to the polymerase. He has 1 patent to his name.
Career Highlights
Todd Appleby is currently employed at Ribapharm Inc., where he continues to advance his research in polymerase inhibitors. His work is pivotal in enhancing the understanding of RNA polymerase mechanisms and their inhibition.
Collaborations
Some of his notable coworkers include Nanhua Hugh Yao and Haoyun An. Their collaborative efforts contribute to the innovative environment at Ribapharm Inc.
Conclusion
Todd Appleby is a distinguished inventor whose work in polymerase inhibition has the potential to impact various biotechnological applications. His contributions to the field are noteworthy and reflect his commitment to innovation.