The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2005
Filed:
Dec. 27, 2002
Nanhua Yao, Irvine, CA (US);
Haoyun an, Carlsbad, CA (US);
Todd Appleby, Laguna Niguel, CA (US);
Shahul Nilar, Irvine, CA (US);
Yili Ding, Fountain Valley, CA (US);
Zhi Hong, Aliso Viejo, CA (US);
Nanhua Yao, Irvine, CA (US);
Haoyun An, Carlsbad, CA (US);
Todd Appleby, Laguna Niguel, CA (US);
Shahul Nilar, Irvine, CA (US);
Yili Ding, Fountain Valley, CA (US);
Zhi Hong, Aliso Viejo, CA (US);
Ribapharm Inc., Costa Mesa, CA (US);
Abstract
A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.