Company Filing History:
2 out of 82 
1 out of 4,447 
Years Active: 2006
Title: The Innovations of Tinggui Yin
Introduction
Tinggui Yin is a notable inventor based in Indianapolis, IN, who has made significant contributions to the field of biomedical research. He holds two patents that focus on advancements in the understanding and treatment of neurological diseases, particularly Alzheimer's disease.
Latest Patents
Yin's latest patents revolve around a novel β-secretase and the modulation of β-secretase activity. This invention details a method for partially purifying this novel β-secretase and its application in assays designed to screen for potential drug candidates targeting Alzheimer's disease and other neurological conditions. The novel β-secretase has an estimated molecular weight of approximately 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively. The pH optimum for this β-secretase is around pH 6.5-7.0, as determined through radiation inactivation analysis.
Career Highlights
Throughout his career, Tinggui Yin has worked with prominent companies in the pharmaceutical industry, including Scios Inc. and Eli Lilly and Company. His work has contributed to the advancement of drug development processes and the understanding of neurological disorders.
Collaborations
Yin has collaborated with several professionals in his field, including Ziyang Zhong and Barbara Cordell. These collaborations have likely enhanced the research and development of his innovative ideas.
Conclusion
Tinggui Yin's contributions to the field of biomedical research, particularly through his patents on β-secretase, highlight his role as an influential inventor. His work continues to pave the way for potential breakthroughs in the treatment of Alzheimer's disease and other neurological disorders.