The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 08, 2006
Filed:
May. 09, 2000
Ziyang Zhong, Union City, CA (US);
Barbara Cordell, Palo Alto, CA (US);
Diana Hom Quon, Redwood City, CA (US);
Yu-wang Liu, Santa Clara, CA (US);
Qiang Xu, Cupertino, CA (US);
Frauke Schimmöller, Menlo Park, CA (US);
Paul Andrew Hyslop, Indianapolis, IN (US);
Edward Marion Johnstone, Indianapolis, IN (US);
Sheila Parks Little, Indianapolis, IN (US);
Steven Wyatt Queener, Indianapolis, IN (US);
Tinggui Yin, Indianapolis, IN (US);
Ziyang Zhong, Union City, CA (US);
Barbara Cordell, Palo Alto, CA (US);
Diana Hom Quon, Redwood City, CA (US);
Yu-Wang Liu, Santa Clara, CA (US);
Qiang Xu, Cupertino, CA (US);
Frauke Schimmöller, Menlo Park, CA (US);
Paul Andrew Hyslop, Indianapolis, IN (US);
Edward Marion Johnstone, Indianapolis, IN (US);
Sheila Parks Little, Indianapolis, IN (US);
Steven Wyatt Queener, Indianapolis, IN (US);
Tinggui Yin, Indianapolis, IN (US);
Scios, Inc., Sunnyvale, CA (US);
Abstract
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.