Company Filing History:
Years Active: 2010-2013
Title: Innovations and Contributions of Timothy A. Cross
Introduction
Timothy A. Cross is a notable inventor based in Tallahassee, Florida. He has made significant contributions to the field of membrane proteins, particularly in understanding their mechanisms of action and potential applications. With a total of 4 patents to his name, his work has advanced the scientific community's knowledge of protein behavior and interactions.
Latest Patents
One of Timothy A. Cross's latest patents is focused on membrane proteins, specifically the M2 protein from the influenza A virus. This invention provides an atomistic functional understanding of the M2 protein, which is an acid-activated selective proton channel. The patent reveals the structure of the M2 conductance domain in a lipid bilayer, highlighting features that were previously unattainable from detergent-solubilized structures. It also details a mechanism for acid activation and proton conductance, elucidating the interactions between histidines and the tryptophan gate.
Another significant patent involves a solid-state NMR method for screening cell membrane protein binding drug candidates. This method utilizes solid-state NMR spectroscopy to detect ligand-cell membrane protein binding. By forming a lipid bilayer inside nanopores of an anodic aluminum oxide substrate, the method allows for the analysis of potential binding affinities of various ligands to membrane proteins. The comparison of NMR spectra before and after ligand treatment provides insights into protein binding dynamics.
Career Highlights
Timothy A. Cross is affiliated with the Florida State University Research Foundation, Inc., where he continues to conduct research and develop innovative solutions in the field of membrane proteins. His work has garnered attention for its potential applications in drug discovery and understanding viral mechanisms.
Collaborations
Throughout his career, Timothy has collaborated with esteemed colleagues, including William W. Brey and Alexej I. Smirnov. These collaborations have further enriched his research and contributed to the advancement of knowledge in his field.
Conclusion
Timothy A. Cross's contributions to the understanding of membrane proteins and their applications are invaluable. His innovative patents and ongoing research continue to impact the scientific community positively.