The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 2013
Filed:
May. 26, 2011
Mukesh Sharma, Tallahassee, FL (US);
Myunggi Yi, Busan, KR;
Hao Dong, Tallahassee, FL (US);
Huajun Qin, Tallahassee, FL (US);
David D. Busath, Orem, UT (US);
Huan-xiang Zhou, Tallahassee, FL (US);
Timothy A. Cross, Tallahassee, FL (US);
Mukesh Sharma, Tallahassee, FL (US);
Myunggi Yi, Busan, KR;
Hao Dong, Tallahassee, FL (US);
Huajun Qin, Tallahassee, FL (US);
David D. Busath, Orem, UT (US);
Huan-Xiang Zhou, Tallahassee, FL (US);
Timothy A. Cross, Tallahassee, FL (US);
Florida State University Research Foundation, Tallahassee, FL (US);
Abstract
The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance.