Company Filing History:
Years Active: 2010-2013
Title: Tiiu Mandel: Innovator in Viral Expression Technologies
Introduction
Tiiu Mandel is a notable inventor based in Tartu, Estonia. He has made significant contributions to the field of biotechnology, particularly in the development of viral expression plasmids. With a total of two patents to his name, Mandel's work focuses on the production of proteins, antibodies, enzymes, and virus-like particles.
Latest Patents
Mandel's latest patents include innovative technologies that enhance the production and maintenance of plasmids. One patent details the use of viral expression plasmids for the production of various biological products. This disclosure highlights the EBV FR-element, which comprises EBNA1 multimeric binding sites that facilitate stable maintenance replication of mouse polyomavirus core origin plasmids in the presence of BPV-1 E2 protein and PyV large T-antigen. Another patent focuses on vectors and cell lines that enable extended episomal maintenance replication of hybrid plasmids. This technology demonstrates that the BPV-1 E2 protein-dependent minichromosome maintenance element can provide stable maintenance replication functions, with a low frequency of plasmid loss during cell generations.
Career Highlights
Throughout his career, Tiiu Mandel has worked with prominent companies in the biotechnology sector, including Kosagen Cell Factory OÜ and Icosagen Cell Factory OÜ. His expertise in viral expression technologies has positioned him as a key figure in the development of advanced biotechnological solutions.
Collaborations
Mandel has collaborated with notable colleagues, including Toomas Silla and Ingrid Tagen, who have contributed to his research endeavors. Their combined efforts have furthered the understanding and application of viral expression systems in biotechnology.
Conclusion
Tiiu Mandel's innovative work in viral expression technologies has made a significant impact in the field of biotechnology. His patents and collaborations reflect a commitment to advancing scientific knowledge and practical applications in the production of biological products.