This inventor holds 2 USPTO granted patents. Top assignee: Johns Hopkins University. Active years: 2010-2017.
Company Filing History:
Years Active: 2010-2017
Title: The Innovative Contributions of Tian-li Wang
Introduction
Tian-li Wang is a prominent inventor based in Baltimore, MD (US). She has made significant contributions to the field of cancer research, particularly through her innovative patents. With a total of 2 patents, her work focuses on understanding genetic mutations and alterations in cancer cells.
Latest Patents
One of her latest patents is titled "P13K pathway mutations in cancer." This research highlights the critical role of protein kinases in pathways that affect cellular growth and invasion. Wang and her team analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. They identified mutations in eight genes, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway. The findings suggest that mutations in these genes have equivalent tumorigenic effects, indicating that the PI3K pathway is a major target for mutational activation in colorectal cancers. This research opens new avenues for therapeutic intervention.
Another significant patent is "Digital Karyotyping." This method provides a quantitative analysis of DNA copy number at high resolution, which is crucial for understanding many human diseases, including cancers. The approach involves isolating and enumerating short sequence tags from specific genomic loci. Wang's analysis of human cancer cells using this method identified gross chromosomal changes, amplifications, and deletions, including previously unknown alterations. Digital Karyotyping offers a systematic means for detecting DNA copy number changes on a genomic scale.
Career Highlights
Tian-li Wang is affiliated with Johns Hopkins University, where she continues her groundbreaking research. Her work has garnered attention for its potential impact on cancer treatment and understanding genetic mutations.
Collaborations
Wang has collaborated with notable colleagues, including Victor E Velculescu and Kenneth W Kinzler. These partnerships have further enhanced her research and contributions to the scientific community.
Conclusion
Tian-li Wang's innovative patents and research in cancer genetics demonstrate her commitment to advancing medical science. Her work not only contributes to our understanding of cancer but also paves the way for future therapeutic developments.