The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 27, 2010
Filed:
Nov. 13, 2003
Tian-li Wang, Baltimore, MD (US);
Victor Velculescu, Dayton, MD (US);
Kenneth Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Tian-Li Wang, Baltimore, MD (US);
Victor Velculescu, Dayton, MD (US);
Kenneth Kinzler, Bel Air, MD (US);
Bert Vogelstein, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Alterations in the genetic content of a cell underlie many human diseases, including cancers. A method called Digital Karyotyping provides quantitative analysis of DNA copy number at high resolution. This approach involves the isolation and enumeration of short sequence tags from specific genomic loci. Analysis of human cancer cells using this method identified gross chromosomal changes as well as amplifications and deletions, including regions not previously known to be altered. Foreign DNA sequences not present in the normal human genome could also be readily identified. Digital Karyotyping provides a broadly applicable means for systematic detection of DNA copy number changes on a genomic scale.