Location History:
- Somerville, MA (US) (1981)
- Stafford Springs, CT (US) (1981)
Company Filing History:
Years Active: 1981
Title: The Innovations of Thomas R. Skopek
Introduction
Thomas R. Skopek is a notable inventor based in Somerville, MA (US). He has made significant contributions to the field of genetic toxicology through his innovative patents. With a total of 2 patents, Skopek's work focuses on assays for mutagenesis, which are crucial for understanding genetic damage caused by various agents.
Latest Patents
Skopek's latest patents include an "Assay for mutagenesis in heterozygous diploid human lymphoblasts." This assay is designed to determine mutagenic damage resulting from the administration of known or suspected mutagens to diploid human lymphoblastoid cell lines. The assay utilizes gene loci for thymidine kinase, uridine kinase, or cytidine deaminase, employing heterozygotes of human lymphoblastoid cells for accurate results.
Another significant patent is the "Assay for mutagenesis in bacterial cells." This assay aims to assess mutagenic damage in bacterial cells, such as Salmonella typhimurium, after exposure to mutagenic agents. The bacterial cells are plated in the presence of a purine analog, and resistance to these analogs serves as a genetic marker. This bioassay system is valuable for genetic toxicologists in evaluating potential genetic hazards from various suspected or known mutagens, including newly-developed chemicals.
Career Highlights
Skopek is affiliated with the Massachusetts Institute of Technology, where he continues to advance research in genetic toxicology. His work has garnered attention for its relevance in assessing the safety of chemicals and understanding genetic mutations.
Collaborations
Throughout his career, Skopek has collaborated with esteemed colleagues, including William G. Thilly and Howard L. Liber. These collaborations have further enriched his research and contributed to the field of genetic toxicology.
Conclusion
Thomas R. Skopek's innovative patents and research in mutagenesis assays highlight his significant contributions to genetic toxicology. His work not only enhances our understanding of genetic damage but also aids in evaluating the safety of various chemical agents.