Company Filing History:
4 out of 636 
3 out of 2,106 
3 out of 2,611 
Years Active: 1997-2003
Title: Thomas M. Ryan: Innovator in Hemoglobin Synthesis
Introduction
Thomas M. Ryan is a notable inventor based in Birmingham, AL (US), recognized for his contributions to the field of biotechnology. He holds a total of 4 patents, focusing primarily on the synthesis of functional human hemoglobin and other proteins in transgenic non-human mammals. His work has significant implications for medical science and genetic engineering.
Latest Patents
Ryan's latest patents include groundbreaking inventions such as the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals. This invention is based on the discovery that two of the five hypersensitivity sites of the β-globin locus are sufficient to achieve high-level expression of human α- or β-globin transgenes. Another notable patent involves novel recombinant nucleic acid vectors that can produce α-globin and other proteins in quantity within the red blood cells of transgenic animals or erythroid cell cultures. These vectors comprise major DNase I hypersensitivity sites associated with the β-globin locus, allowing for the creation of transgenic animals that express human hemoglobin in their erythroid tissues.
Career Highlights
Throughout his career, Thomas M. Ryan has worked with esteemed organizations such as the UAB Research Foundation and the University of Washington. His research has contributed to advancements in genetic engineering and therapeutic applications, particularly in the production of human hemoglobin.
Collaborations
Ryan has collaborated with prominent scientists in his field, including Tim M. Townes and Richard D. Palmiter. These collaborations have furthered research efforts and innovation in biotechnology.
Conclusion
Thomas M. Ryan's innovative work in the synthesis of human hemoglobin and transgenic technology has made a significant impact in the field of biotechnology. His patents and collaborations continue to influence advancements in medical science and genetic research.