The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2003
Filed:
Sep. 01, 1999
Applicant:
Inventors:
Tim M. Townes, Birmingham, AL (US);
Thomas M. Ryan, Birmingham, AL (US);
Richard D. Palmiter, Seattle, WA (US);
Ralph L. Brinster, Gladwyne, PA (US);
Richard R. Behringer, Philadelphia, PA (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 6/7027 ; C12N 1/500 ; C12P 2/100 ;
U.S. Cl.
CPC ...
A01K 6/7027 ; C12N 1/500 ; C12P 2/100 ;
Abstract
The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the &bgr;-globin locus are sufficient to result in high level expression of human &agr;- or &bgr;-globin transgenes.