Thomas M Jessell

Title: **Thomas M. Jessell: Pioneer in Stem Cell Research and Innovation**

Introduction

Thomas M. Jessell, based in the Bronx, New York, is a prominent inventor with an impressive portfolio of 23 patents. His groundbreaking work primarily focuses on developing innovative solutions for degenerative nervous system disorders through the application of stem cell technology.

Latest Patents

Among his latest patents, two significant inventions stand out. The first is a **stem cell-based culture system for drug development**, which comprises differentiated stem cells suitable for identifying therapeutic agents for degenerative nervous system disorders. This invention leverages the discovery that co-cultures of astrocytes expressing a mutated SOD1 gene and stem-cell-derived motor neurons undergo cell death via a Bax-dependent mechanism, effectively modeling motor neuron death associated with amyotrophic lateral sclerosis (ALS).

The second patent pertains to **methods for generating caudal motor neurons** from embryonic stem cells under conditions that are essentially free of retinoids. This work discloses techniques for cultivating not only motor neurons expressing the Hoxc8 transcription factor but also various other types such as caudal brachial, thoracic, and lumbar motor neurons. The patent also includes methods for transplanting generated motor neurons into subjects and identifies a population of motor neuron cells that are enriched for those expressing Foxp1, as well as genes associated with Spinal Muscular Atrophy (SMA) or ALS.

Career Highlights

Thomas M. Jessell has had a significant impact during his career, particularly within esteemed academic institutions. He has worked with Columbia University in the City of New York and the University of California, where he contributed immensely to the field of neuroscience and stem cell research. His innovative approaches have opened new avenues for treatments and interventions for debilitating neurological diseases.

Collaborations

Throughout his career, Jessell has collaborated with notable colleagues, including Jane Dodd and Marc Tessier-Lavigne. These collaborations have enriched his research, allowing for a more interdisciplinary approach to the challenges posed by motor neuron diseases.

Conclusion

In conclusion, Thomas M. Jessell is a leading figure in the realm of stem cell innovation and neuroscience research. His contributions, evident through his numerous patents and collaborations, have not only advanced our understanding of motor neuron disorders but also paved the way for potential therapeutic applications. As he continues to innovate, his work stands as a testament to the transformative power of scientific exploration and discovery.