The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 25, 2007
Filed:
Aug. 31, 2001
Thomas M. Jessell, Bronx, NY (US);
James Briscoe, London, GB;
Johan Ericson, Hasselby, SE;
John L. R. Rubenstein, San Francisco, CA (US);
Maike Sander, Hamburg, DE;
Thomas M. Jessell, Bronx, NY (US);
James Briscoe, London, GB;
Johan Ericson, Hasselby, SE;
John L. R. Rubenstein, San Francisco, CA (US);
Maike Sander, Hamburg, DE;
The Trustees of Columbia University in the City of New York, New York, NY (US);
The Regents of the University of California, Alameda, CA (US);
Abstract
This invention provides a method of converting a stem cell into a ventral neuron which comprises introducing into the stem cell a nucleic acid which expresses homeodomain transcription factor Nkx6.1 or Nkx6.2 protein in the stem cell so as to thereby convert the stem cell into the ventral neuron. Provided are methods of diagnosing a motor neuron degenerative disease in a subject. Also provides is a method of treating neuronal degeneration in a subject which comprises implanting in diseased neural tissue of the subject a neural stem cell which is capable of expressing homeodomain Nkx6.1 or Nkx6.2 protein under conditions such that the stem cell is converted into a motor neuron after implantation, thereby treating neuronal degeneration in the subject.