Thomas L Fillmore

Title: Thomas L. Fillmore: Innovator in Biological Analysis

Introduction

Thomas L. Fillmore is a distinguished inventor based in Kennewick, WA (US). He has made significant contributions to the field of biological analysis, particularly through his innovative patent that addresses the quantification of target analytes in complex biological systems. His work is crucial for advancing research in various scientific domains.

Latest Patents

Thomas L. Fillmore holds a patent titled "Process for ultra-sensitive quantification of target analytes in complex biological systems." This patent describes antibody-free processes that enable accurate quantification of low-abundance target analytes in complex samples. The processes utilize high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions can be achieved through on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. This innovative approach allows for quantification on individual or multiplexed fractions, with applications in analyzing very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.

Career Highlights

Thomas L. Fillmore is associated with the Battelle Memorial Institute, where he has been able to apply his expertise in biological analysis. His work has contributed to the development of advanced methodologies that enhance the accuracy and efficiency of biological research.

Collaborations

Throughout his career, Thomas has collaborated with notable colleagues, including Tujin Shi and Weijun Qian. These collaborations have further enriched his research and innovation in the field.

Conclusion

Thomas L. Fillmore is a prominent inventor whose work in the quantification of target analytes has significant implications for biological research. His innovative approaches continue to pave the way for advancements in the analysis of complex biological systems.