Thomas J Fraites

Title: Thomas J Fraites: Innovator in Recombinant AAV Virions

Introduction

Thomas J Fraites is a notable inventor based in Gainesville, FL (US). He has made significant contributions to the field of gene therapy through his innovative work on recombinant AAV virions. His research focuses on the production and purification of these viral vectors, which are essential for delivering genetic material into cells.

Latest Patents

Fraites holds a patent for the "Production of pseudotyped recombinant AAV virions." This patent describes vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes, along with Adenovirus transcription products that provide necessary helper functions. The purification methods he developed generate pseudotyped rAAV virion stocks that are 99% pure, with titers ranging from 1×10–1×10 vector genomes/ml.

Career Highlights

Fraites is affiliated with the University of Florida Research Foundation, Incorporated, where he continues to advance his research in viral vector technology. His work has implications for various therapeutic applications, particularly in the treatment of genetic disorders.

Collaborations

Throughout his career, Fraites has collaborated with esteemed colleagues, including Richard O Snyder and Sergei Zolotukhin. These partnerships have enhanced the scope and impact of his research.

Conclusion

Thomas J Fraites is a pioneering inventor whose work in recombinant AAV virions is paving the way for advancements in gene therapy. His contributions are vital to the ongoing development of effective treatments for genetic diseases.