Location History:
- Baltimore, MD (US) (2014)
- Nobelsville, TN (US) (2017 - 2020)
Company Filing History:
Years Active: 2014-2020
Title: Innovations in Cancer Genetics: The Contributions of Thomas Barber
Introduction
Thomas Barber, an innovative inventor based in Noblesville, TN, has made significant contributions to the field of cancer genetics. He holds three patents that focus on understanding genetic mutations associated with human breast and colorectal cancers. His work not only sheds light on the complexities of tumor biology but also opens up new avenues for diagnostics and therapeutic strategies.
Latest Patents
Among his latest patents, Barber's research delves into the consensus coding sequences of human breast and colorectal cancers. His analysis of 13,023 genes from 11 breast and 11 colorectal tumor samples revealed that individual tumors accumulate an average of approximately 90 mutant genes. Notably, only a selective subset of these mutations contributes to the neoplastic process. Through stringent criteria, Barber identified 189 genes—which average around 11 mutations per tumor—demonstrating statistically significant mutation frequencies. Remarkably, most of these identified genes were not previously known to be genetically altered in tumors and are poised to influence a variety of cellular functions, including transcription, adhesion, and invasion. This groundbreaking data provides a comprehensive genetic landscape of two prevalent human cancer types and highlights new targets for diagnostic and therapeutic intervention and monitoring.
Career Highlights
Thomas Barber's career is marked by his commitment to advancing the understanding of cancer genomics. His role at The Johns Hopkins University has allowed him to be at the forefront of revolutionary research that impacts the lives of many. With three patents to his name, Barber's contributions have been instrumental in shaping modern approaches to cancer diagnostics and treatment.
Collaborations
In his journey, Barber has collaborated with notable colleagues such as Tobias Sjoblom and Sian Jones. Together, they have combined their expertise to drive innovative research forward, making significant strides in the understanding of cancer genetics and its implications for patient care.
Conclusion
Thomas Barber's innovative work in the field of cancer genetics exemplifies the profound impact that research and invention can have on our understanding of complex diseases. His contributions not only pave the way for new breakthroughs in cancer diagnostics and therapeutics but also inspire future generations of inventors and researchers to explore the boundaries of scientific knowledge.