The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
Mar. 19, 2020
The Johns Hopkins University, Baltimore, MD (US);
Tobias Sjoblom, Uppsala, SE;
Sian Jones, Baltimore, MD (US);
D. Williams Parsons, Bellaire, TX (US);
Laura D. Wood, Baltimore, MD (US);
Jimmy Cheng-Ho Lin, Baltimore, MD (US);
Thomas Barber, Nobelsville, TN (US);
Diana Mandelker, Baltimore, MD (US);
Bert Vogelstein, Baltimore, MD (US);
Kenneth W. Kinzler, Baltimore, MD (US);
Victor E. Velculescu, Dayton, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.