Company Filing History:
Years Active: 2014-2020
Title: **Diana Mandelker: Pioneering Research in Cancer Genomics**
Introduction
Diana Mandelker, a distinguished inventor based in Baltimore, MD, is making significant strides in the field of cancer research. With 3 patents to her name, her innovative work focuses on understanding the genetic alterations associated with human cancers, particularly breast and colorectal cancers. Her research aims to provide new insights into cancer diagnostics and therapeutics.
Latest Patents
Among her notable patents is the groundbreaking analysis titled "Consensus coding sequences of human breast and colorectal cancers." This work involves an extensive examination of 13,023 genes across 11 breast and 11 colorectal cancers. The findings revealed that individual tumors accumulate an average of approximately 90 mutant genes, with only a specific subset contributing to the neoplastic process. Through rigorous criteria, Mandelker and her team identified 189 genes that were significantly mutated, which were previously unknown to be altered in tumors. These genes influence various cellular functions such as transcription, adhesion, and invasion, thus paving the way for new targets for both diagnostic and therapeutic interventions.
Career Highlights
Diana Mandelker currently serves as a researcher at The Johns Hopkins University, an institution renowned for its contributions to biomedical research. Her expertise in genomics has enabled her to better understand the intricate mechanisms behind tumor development and progression. Her work not only contributes to academic advancements but also enhances clinical applications in oncology.
Collaborations
Mandelker collaborates with esteemed colleagues, including Tobias Sjoblom and Sian Jones. These partnerships foster a collaborative research environment, allowing for a comprehensive exploration of cancer genomics that benefits from diverse expertise and perspectives.
Conclusion
Diana Mandelker's innovative contributions to cancer research highlight the critical importance of understanding genetic mutations in the fight against cancer. Her discoveries not only redefine the genetic landscape of breast and colorectal cancers but also open new avenues for therapeutic interventions and diagnostic advancements. As her work continues to unfold, it promises to impact the future of cancer treatment significantly.