Thamara K Janaratne

Title: Thamara K Janaratne: Innovator in Biologic Modifications

Introduction

Thamara K Janaratne is a prominent inventor based in San Diego, CA. She has made significant contributions to the field of biologic modifications, holding a total of 3 patents. Her work focuses on developing compounds that enhance activity under hypoxic conditions, which is crucial for targeting specific biologic entities.

Latest Patents

Janaratne's latest patents include innovative compositions and methods for modifying one or more biologic targets. These targets encompass cells, DNA, proteins, enzymes, and subjects in need of such modifications. The compositions can exist as monomers or multimers and are particularly effective in biologic environments with enhanced activity in hypoxic conditions. This specificity is vital for targeting hypoxic biologic entities, such as tumorigenic cells and those undergoing uncontrolled growth. Typically, a composition comprises a complex with an overall charge of 2+ or greater, featuring at least one ruthenium atom attached to a redox-active ligand. This ligand plays a crucial role in maintaining the separation of multiple ruthenium atoms. Additionally, suitable compositions may include a terminal ligand made up of a heterocyclic aromatic compound. When administered to a biologic target, these compositions modify the target without the need for additional compounds, and they are generally catalytic and regenerative in the presence of a reducing agent.

Career Highlights

Throughout her career, Janaratne has worked with esteemed institutions, including the University of Texas System. Her innovative research has positioned her as a leader in her field, contributing to advancements in biologic modifications.

Collaborations

Janaratne has collaborated with notable professionals, including Frederick M MacDonnell and Sanjay Awashti. These partnerships have further enriched her research and development efforts.

Conclusion

Thamara K Janaratne is a trailblazer in the realm of biologic modifications, with a focus on enhancing activity in hypoxic conditions. Her contributions through her patents and collaborations continue to impact the field significantly.