Location History:
- Glen Burnie, MD (US) (1997)
- Gainesville, FL (US) (2002)
- Alachua, FL (US) (2006 - 2012)
Company Filing History:
3 out of 2,930 
2 out of 3,688 
1 out of 20 Years Active: 1997-2012
Title: Terence R Flotte: Innovator in Gene Therapy
Introduction
Terence R Flotte is a prominent inventor based in Alachua, FL (US), known for his significant contributions to the field of gene therapy. With a total of 4 patents, Flotte has focused on developing innovative solutions for treating genetic disorders, particularly cystic fibrosis.
Latest Patents
Flotte's latest patents include groundbreaking work on compositions for treating cystic fibrosis. This invention relates to the use of AAV vectors and constructs to provide gene therapy to cystic fibrosis patients. Another notable patent involves the production of pseudotyped recombinant AAV virions. This patent describes the use of vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes, along with Adenovirus transcription products that provide necessary helper functions. The purification methods developed in this patent generated pseudotyped rAAV virion stocks that were 99% pure, with titers of 1×10–1×10 vector genomes/ml.
Career Highlights
Throughout his career, Flotte has worked with esteemed institutions such as the University of Florida Research Foundation and The Johns Hopkins University. His work has significantly advanced the understanding and treatment of cystic fibrosis, showcasing his dedication to improving patient outcomes through innovative research.
Collaborations
Flotte has collaborated with notable colleagues, including William B Guggino and Barry John Byrne, further enhancing the impact of his research in the field of gene therapy.
Conclusion
Terence R Flotte's contributions to gene therapy, particularly in the treatment of cystic fibrosis, highlight his role as a leading inventor in the field. His innovative patents and collaborations continue to pave the way for advancements in medical science.