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Title: Taro Kimura: Innovator in Gene Carrier Technology
Introduction
Taro Kimura is a prominent inventor based in Dazaifu, Japan. He has made significant contributions to the field of gene carrier technology, holding a total of 2 patents. His innovative work focuses on the development of gene carriers that utilize unique polymer structures to enhance nucleic acid delivery.
Latest Patents
Kimura's latest patents include a gene carrier composed of a hydrogen-bonding polymer. This polymer features a chain with hydrogen-bonding sites that mimic the conformation of nucleic acids. The polymer chain's helix parameters are similar to those of nucleic acids, making it an effective vector for nucleic acid delivery. In a preferred embodiment, the hydrogen-bonding polymer is made from β-1,3-glucan, such as schizophyllan. This carrier is expected to serve as both a vector and a separator for nucleic acids, facilitating the formation of complexes with nucleic acids for effective delivery.
Another notable patent involves gene carriers utilizing β-1,3-glucan, which has been chemically modified to include nucleic acid-binding functional groups. This modification allows for the formation of complexes with nucleic acids when the modified polymer is introduced to a nucleic acid solution. The process involves dissolving triple helix β-1,3-glucan in a polar organic solvent to create single-stranded β-1,3-glucan, which can then bind to nucleic acids upon the replacement of the solvent with water.
Career Highlights
Throughout his career, Taro Kimura has worked with esteemed organizations such as the Japan Science and Technology Agency and Mitsui Sugar Co., Ltd. His experience in these institutions has contributed to his expertise in polymer chemistry and gene delivery systems.
Collaborations
Kimura has collaborated with notable colleagues, including Kazuo Sakurai and Seiji Shinkai. These partnerships have fostered innovation and advancement in the field of gene carriers.
Conclusion
Taro Kimura's contributions to gene carrier technology highlight his role as a leading inventor in this specialized field. His innovative patents and collaborations reflect his commitment to advancing nucleic acid delivery systems.