Takuro Horii

Title: Takuro Horii: Innovator in DNA Methylation Editing

Introduction

Takuro Horii is a prominent inventor based in Gunma, Japan. He has made significant contributions to the field of genetic engineering, particularly in DNA methylation editing. With a total of 3 patents to his name, Horii is recognized for his innovative approaches to modifying genetic material.

Latest Patents

Horii's latest patents include a DNA methylation editing kit and a DNA methylation editing method. The DNA methylation editing kit comprises a fusion protein of inactivated CRISPR-associated endonuclease Cas9 (dCas9) with a tag peptide array. This kit also includes a fusion protein of a tag peptide-binding portion and a methylase or demethylase, along with guide RNA(s) that are complementary to a DNA sequence within 1 kb of the desired site of methylation or demethylation. Additionally, he has developed a production method for conditional knockout animals, which involves introducing recombinase recognition sequences into a target region on a chromosome at different timings to produce a floxed animal.

Career Highlights

Horii is affiliated with Gunma University, where he continues to advance research in genetic engineering. His work has garnered attention for its potential applications in biotechnology and medicine.

Collaborations

Some of his notable coworkers include Izuho Hatada and Sumiyo Morita, who have collaborated with him on various research projects.

Conclusion

Takuro Horii's contributions to DNA methylation editing highlight his role as an influential inventor in the field of genetic engineering. His innovative patents and ongoing research at Gunma University continue to pave the way for advancements in biotechnology.