Taichi Chen

Title: Taichi Chen: Innovator in N-Acetylglucosamine Synthesis

Introduction

Taichi Chen is a prominent inventor based in Wuxi, China. He has made significant contributions to the field of genetic engineering, particularly in the synthesis of N-acetylglucosamine. With a total of 2 patents, his work is paving the way for advancements in industrial fermentation processes.

Latest Patents

Taichi Chen's latest patents include a method for promoting N-acetylglucosamine synthesis by using the GlcN6P responsive element. This innovative method utilizes the strain BSGNY-P-glmS-P-GNA1, integrating a CRISPRi system regulated by the GlcN6P responsive element into the genome. This approach dynamically weakens the competitive pathway for N-acetylglucosamine synthesis, achieving a production level of 131.6 g/L during fed-batch fermentation without accumulating by-products. Another notable patent is a method for producing N-acetylglucosamine by co-utilizing glucose and xylose based on CRISPRi. This method also employs the strain BSGNY-P-glmS-P-GNA1, where dCas9 induced by xylose and three sgRNA expression fragments are integrated into the genome. This process results in a GlcNAc titer of 20.5 g/L and a yield of 0.612 g/g glucose, laying the groundwork for further metabolic engineering transformations.

Career Highlights

Taichi Chen is affiliated with Jiangnan University, where he continues to conduct research and develop innovative methods in his field. His work has garnered attention for its potential applications in industrial fermentation and genetic engineering.

Collaborations

Taichi Chen collaborates with notable colleagues, including Long Liu and Jian Chen, who contribute to his research endeavors and innovations.

Conclusion

Taichi Chen's contributions to the field of N-acetylglucosamine synthesis through innovative methods highlight his role as a leading inventor in genetic engineering. His patents not only advance scientific knowledge but also have significant implications for industrial applications.