Company Filing History:
Years Active: 2019-2021
Title: Susan M Rupp: Innovator in DNA Polymerase Technology
Introduction
Susan M Rupp is a prominent inventor based in Marion, IA (US), known for her significant contributions to the field of biotechnology. She holds 2 patents that focus on enhancing the specificity and efficiency of DNA amplification processes. Her work has implications for various applications in genetic research and diagnostics.
Latest Patents
One of her latest patents is titled "DNA polymerase mutants having enhanced template discrimination activity." This invention relates to mutant DNA polymerases that exhibit improved template discrimination compared to their unmodified counterparts. The amino acid sequence of these mutant DNA polymerases includes at least one substitution at residue positions structurally and functionally homologous or orthologous to positions 783 or 784 of an unmodified Taq DNA polymerase.
Another notable patent is "RNase H-based assays utilizing modified RNA monomers." This patent provides methods and compositions aimed at improving specificity during the amplification of target DNA sequences. The methods utilize an RNase H enzyme, a polymerase, and RNase H enzyme-sensitive, blocked-cleavable oligonucleotide primers in the amplification reactions. The reaction mixtures are optimized with a final concentration of a divalent metal salt comprising 2.0 mM or less of free Mg cation and/or a non-ionic detergent comprising at least about 0.001% polyethylene glycol hexadecyl ether.
Career Highlights
Susan M Rupp is currently associated with Integrated DNA Technologies, Inc., where she continues to innovate in the field of molecular biology. Her work has been instrumental in advancing techniques that enhance the accuracy and efficiency of DNA manipulation.
Collaborations
Throughout her career, Susan has collaborated with notable colleagues, including Joseph Alan Walder and Mark Aaron Behlke. These collaborations have contributed to the development of cutting-edge technologies in DNA research.
Conclusion
Susan M Rupp's contributions to DNA polymerase technology and her innovative patents underscore her role as a leading inventor in the biotechnology field. Her work continues to influence advancements in genetic research and diagnostics.