Sun Hee Rosenthal

Title: **Innovative Contributions of Sun Hee Rosenthal in Plant-Based Recombinant Protein Production**

Introduction

Sun Hee Rosenthal is a prominent inventor located in Santa Ana, California, with a remarkable portfolio of three patents. Her work primarily focuses on advancing plant-based systems for recombinant protein production, contributing significantly to the field of biotechnology and agricultural innovation.

Latest Patents

One of Sun Hee Rosenthal's latest patents involves replicating and non-replicating vectors for recombinant protein production in plants. This technology outlines a plant-based recombinant protein production system that includes a vector with specific 5' UTR and 3′ UTR sequences, where the 3′ UTR contains one or more terminators from an extensive selection. Additionally, the vectors can feature a double terminator setup and a chromatin scaffold/matrix attachment region (MAR), enhancing the effectiveness of the recombination process.

Another notable patent is for a geminiviral vector enabling the expression of Rituximab, a monoclonal antibody. This invention describes a system using either a single vector or multiple separate vectors that contain non-competing replicons for the transient production of both the heavy and light chains of Rituximab in plant leaves. This innovative approach simplifies the previous reliance on non-competing viruses, which in turn enhances the commercial viability of producing complex proteins like Rituximab in plant cells.

Career Highlights

Sun Hee Rosenthal has collaborated with reputable organizations such as Arizona State University and the Arizona Board of Regents on behalf of Arizona. Her academic and professional endeavors have positioned her as a leader in the biotechnological application of plant systems for protein production.

Collaborations

Throughout her career, Rosenthal has worked alongside notable colleagues including Hugh S. Mason and Charles Joel Arntzen, further driving advancements in the field through collaborative research efforts. These partnerships have fostered significant contributions to the landscape of recombinant protein technology.

Conclusion

Sun Hee Rosenthal’s innovative work in plant-based recombinant protein production highlights her contributions to biotechnology and agricultural development. Her patents reflect a commitment to enhancing the efficiency of protein production systems, setting the stage for potential breakthroughs in medical and agricultural applications. With her continued research and collaboration, the future looks promising for advancements in this crucial area of science.