Location History:
- Iowa City, IA (US) (1993 - 1995)
- Fishers, IN (US) (1996)
Company Filing History:
6 out of 902 
1 out of 2,304 
Years Active: 1993-1996
Title: The Innovations of Steven D. Kahl
Introduction
Steven D. Kahl is a prominent inventor based in Iowa City, IA, known for his significant contributions to the field of biochemistry and pharmacology. With a total of 6 patents to his name, Kahl has made remarkable advancements in the understanding and application of ryanodine derivatives.
Latest Patents
Among his latest patents is the invention of an immunogenic ryanodine derivative and related uses. This novel photo-activatable derivative of ryanodine, specifically 9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine, has been conjugated to keyhole limpet hemocyanin (KLH). This innovation has facilitated the production of antibodies with high affinity and specificity to ryanodine. Additionally, Kahl developed a radioimmunoassay specific for ryanodine using these anti-ryanodine antibodies, determining a dissociation constant for ryanodine of 1 nM. Another significant patent involves diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of these abnormal fragments is indicative of malignant hyperthermia susceptibility.
Career Highlights
Kahl has had a distinguished career, contributing to various research initiatives and projects. His work has been instrumental in advancing the understanding of ryanodine receptors and their implications in muscle physiology and pathology.
Collaborations
Throughout his career, Kahl has collaborated with notable figures in the field, including Kevin P. Campbell and James M. Ervasti. These collaborations have further enriched his research and innovations.
Conclusion
Steven D. Kahl's contributions to the field of biochemistry through his innovative patents and collaborations highlight his role as a leading inventor. His work continues to impact the scientific community and advance our understanding of critical biological processes.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.