The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 1993
Filed:
Aug. 06, 1990
Applicant:
Inventors:
Kevin P Campbell, Iowa City, IA (US);
C Michael Knudson, Iowa City, IA (US);
Steven D Kahl, Iowa City, IA (US);
Charles F Louis, St. Paul, MN (US);
James R Mickelson, St. Paul, MN (US);
Assignees:
University of Iowa Research Foundation, Iowa, IA (US);
Regents of the University of Minnesota, Minneapolis, MN (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q / ; C12Q / ; G01N / ; G01N / ;
U.S. Cl.
CPC ...
435-72 ; 435 24 ; 436530 ; 436 63 ; 5303871 ;
Abstract
The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.